Data Sheet

MSDS

Fmoc-His(3-Me)-OH [CAS 252049-16-4]

CAS No:	252049-16-4
Applications:	Neuroscience-Neurodegeneration
MW:	391.42
Formula:	C₂₂H₂₁N₃O₄
SMILES:	O=C(O)[C@H](CC1=CN=CN1C)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O
Purity:	98.0
Description:	Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's A? channel[1][2][3].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only