| Description: | CD3 gamma, part of the TCR-CD3 complex on T-lymphocytes, facilitates TCR-mediated signaling and regulates surface expression. APC-induced TCR activation prompts CD3 gamma, along with CD3D, CD3E, and CD3Z, to transmit signals via ITAMs. Phosphorylation by LCK and FYN initiates downstream signaling. CD3 gamma's diL motif guides constitutive TCR cycling. In TCR-CD3 assembly, CD3 gamma shows versatility, forming heterodimers and trimers, highlighting its pivotal role in T-cell activation and receptor dynamics. CD3 gamma Protein, Human (HEK293, Fc) is the recombinant human-derived CD3 gamma protein, expressed by HEK293, with C-hFc labeled tag. The total length of CD3 gamma Protein, Human (HEK293, Fc) is 94 a.a., with molecular weight of 45-55 kDa. |
