| Description: | TCPTP, a non-receptor tyrosine-specific phosphatase, critically regulates various kinases (INSR, EGFR, JAKs, Src), influencing hematopoiesis, inflammation, cell proliferation, and glucose homeostasis. In the immune system, TCPTP modulates T-cell receptor signaling, inhibiting cytokine pathways (IL2, interferon). It negatively regulates EGF-stimulated cell growth, PDGF receptor-beta signaling, and insulin receptor signaling, impacting glucose homeostasis and liver glucose production through the IL6 pathway. TCPTP's broad influence emphasizes its pivotal role in diverse cellular processes. TCPTP Protein, Human (sf9) is the recombinant human-derived TCPTP protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of TCPTP Protein, Human (sf9) is 314 a.a., with molecular weight of ~37 kDa. |
