| Description: | APT-1/LYPLA1 protein, an acyl-protein thioesterase, hydrolyzes fatty acids from S-acylated cysteine residues in proteins, including G alpha proteins and HRAS. It also depalmitoylates KCNMA1 and potentially ADRB2, while functioning as a lysophospholipase, hydrolyzing lysophosphatidylcholine (lyso-PC) and other lysophospholipids (lyso-PE, lyso-PI, lyso-PS). APT-1/LYPLA1 significantly influences blood coagulation by cleaving plasma phospholipids, generating lysophospholipids for ENPP2, leading to lysophosphatidic acid (LPA) production. APT-1/LYPLA1 Protein, Human (His) is the recombinant human-derived APT-1/LYPLA1 protein, expressed by E. coli, with N-6*His labeled tag. The total length of APT-1/LYPLA1 Protein, Human (His) is 230 a.a., with molecular weight of ~25.0 kDa. |
