| Description: | ITK protein, a tyrosine kinase, plays a crucial role in directing the adaptive immune response by governing the development, function, and differentiation of conventional T-cells and nonconventional NKT-cells. Upon T-cell receptor (TCR) activation by antigen-presenting cells (APC), ITK is recruited to the cell membrane and undergoes phosphorylation by LCK, leading to its full activation. Activated ITK phosphorylates PLCG1, triggering calcium release, nuclear translocation of NFAT, and lymphokine production. ITK's intricate signaling cascade also influences T-cell proliferation and differentiation, highlighting its pivotal role in shaping the adaptive immune response. ITK Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived ITK protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of ITK Protein, Mouse (sf9, His-GST) is 269 a.a., with molecular weight of ~58 kDa. |
