| Description: | HER2/CD340 Protein, a pivotal protein tyrosine kinase, is integral to diverse cell surface receptor complexes, requiring a coreceptor for ligand binding. Its interaction within the neuregulin-receptor complex depends on neuregulins, and GP30 emerges as a potential ligand. HER2 also regulates peripheral microtubules (MTs), influencing their outgrowth and stabilization. Activated HER2 induces the MEMO1-RHOA-DIAPH1 pathway, inhibiting GSK3B, facilitating membrane-bound APC localization, and enabling MACF1-mediated microtubule capture. Additionally, HER2 engages in varied interactions, such as preferential binding to tyrosine-phosphorylated CPNE3 and transcriptional regulation in the nucleus, impacting gene expression and cellular processes. HER2/CD340 Protein, Rat (His) is the recombinant rat-derived HER2/CD340 protein, expressed by E. coli, with C-6*His labeled tag. The total length of HER2/CD340 Protein, Rat (His) is 257 a.a., with molecular weight of ~32 kDa. |
