| Description: | Stem Cell Factor (SCF) functions as a pivotal ligand for KIT, regulating cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving phosphorylation events, key kinases (AKT1, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1), STAT family members, and PLCG1. SCF, in synergy with interleukins, forms heterotetramers, mediating KIT dimerization and autophosphorylation, emphasizing its multifaceted role in cellular processes and developmental pathways. SCF Protein, Rat (His) is the recombinant rat-derived SCF protein, expressed by E. coli, with C-6*His labeled tag. The total length of SCF Protein, Rat (His) is 164 a.a., with molecular weight of ~17 kDa. |
