| Description: | LAG-3 (Lymphocyte activation gene 3) Protein, an inhibitory receptor on antigen-activated T-cells, crucially regulates immunity. Binding to FGL1, LAG-3 delivers inhibitory signals negatively affecting CD8(+) and CD4(+) T-cell proliferation, activation, and effector function. Synergizing with PDCD1/PD-1, LAG-3 inhibits antigen-specific T-cell activation, associating with CD3-TCR at the immunological synapse. Constitutively expressed on regulatory T-cells (Tregs), LAG-3 contributes to suppressive function and immune tolerance. Additionally, LAG-3 negatively regulates plasmacytoid dendritic cell (pDCs) activation, interacting with MHC class II (MHC-II), potentially acting as both a ligand and promoter of APC activation/maturation, influencing Th1 immune response. LAG-3 Protein, Human (HEK293, Fc) is the recombinant human-derived LAG-3 protein, expressed by HEK293, with C-hFc labeled tag. The total length of LAG-3 Protein, Human (HEK293, Fc) is 428 a.a., with molecular weight of 70-90 kDa. |
