| Description: | MPZL1, a cell surface receptor intricately involved in signal transduction processes, plays a pivotal role in recruiting PTPN11/SHP-2 to the cell membrane, establishing itself as a putative substrate for PTPN11/SHP-2. As a major receptor for concanavalin-A (ConA), MPZL1 contributes to cellular signaling induced by ConA, likely involving Src family tyrosine-protein kinases. The isoform 3 variant appears to exert a dominant negative effect, inhibiting the tyrosine phosphorylation of MPZL1 induced by ConA. Notably, isoform 1, distinct from isoform 2 and isoform 3, is implicated in the regulation of integrin-mediated cell motility. The receptor also engages in interactions with phosphorylated PTPN11/SHP-2, underscoring its multifaceted involvement in signal transduction cascades. MPZL1 Protein, Human (HEK293, His) is the recombinant human-derived MPZL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MPZL1 Protein, Human (HEK293, His) is 127 a.a., with molecular weight of 20-28 kDa. |
