| Description: | MXRA8, a transmembrane protein, intricately modulates signaling pathways, potentially through interaction with integrin ITGAV:ITGB3. It mediates heterophilic cell-cell interactions, inhibits osteoclastogenesis via TNFSF11/RANKL and CSF1, and suppresses VEGF-induced AKT and p38 MAP kinase activation. MXRA8 promotes cartilage formation, growth plate chondrocyte proliferation, primary cilia formation, and hedgehog pathway gene expression. In angiogenesis, it suppresses endothelial cell migration and promotes apoptosis, while interfering with VTN-mediated ITGAV:ITGB3 signaling and PTK2/FAK activation. MXRA8's role extends to blood-brain barrier maturation. It forms cis homodimers and inhibits ITGAV:ITGB3 heterodimer formation, showcasing its multifaceted regulatory impact on cellular processes and tissue homeostasis. MXRA8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MXRA8 protein, expressed by HEK293, with C-His labeled tag. The total length of MXRA8 Protein, Mouse (HEK293, His) is 321 a.a., with molecular weight of 42-52 kDa. |
