Nonactin [CAS 6833-84-7] (10mM in DMSO)
Partner: MedChemexpress LLC
| CAS No: | 6833-84-7 |
| Applications: | Neuroscience-Neurodegeneration |
| MW: | 736.93 |
| Formula: | C40H64O12 |
| SMILES: | O=C(O[C@H](C)C[C@@]1([H])CC[C@@](O1)([H])[C@H](C)C(O[C@@H](C)C[C@]2([H])CC[C@](O2)([H])[C@@H](C)C(O[C@H](C)C[C@@]3([H])CC[C@@](O3)([H])[C@@H]4C)=O)=O)[C@H](C)[C@@](O5)([H])CC[C@@]5([H])C[C@H](C)OC4=O |
| Purity: | 99.0 |
| Description: | Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+[1]. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant ?-catenin[2]. Nonactin inhibits the surface expression of endogenous HSP60[3]. |
| Shipping Conditions: | Ship on cold packs |
| Usage: | Research Use Only |
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