Data Sheet

MSDS

PF-CBP1 hydrochloride [CAS 2070014-93-4] (10mM in DMSO)

CAS No:	2070014-93-4
Applications:	Neuroscience-Neurodegeneration
MW:	525.08
Formula:	C₂₉H₃₇ClN₄O₃
SMILES:	CCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1.Cl[H]
Purity:	99.99
Description:	PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinson's disease, et al[1].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only