Data Sheet

MSDS

AS1949490 [CAS 1203680-76-5]

CAS No:	1203680-76-5
Applications:	Neuroscience-Neuromodulation
MW:	371.88
Formula:	C₂₀H₁₈ClNO₂S
SMILES:	O=C(C1=C(OCC2=CC=C(Cl)C=C2)C=CS1)N[C@H](C3=CC=CC=C3)C
Purity:	99.90
Description:	AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 �M for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes[1][2].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only