Data Sheet

MSDS

Pexidartinib [CAS 1029044-16-3]

CAS No:	1029044-16-3
Applications:	Cancer-Kinase/protease
MW:	417.81
Formula:	C₂₀H₁₅ClF₃N₅
SMILES:	FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
Purity:	99.64
Description:	Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only