Data Sheet

MSDS

NecroIr1

Applications:	Cancer-Kinase/protease
MW:	823.36
Formula:	C₄₀H₂₉ClIrN₅O
SMILES:	CC1=CC(C2=[N]3C=CC(C4=NC(C=CC=C5)=C5O4)=C2)=[N]([Ir]67([N]8=CC=CC=C8C9=C7C=CC=C9)3[N]%10=CC=CC=C%10C%11=C6C=CC=C%11)C=C1.[Cl-]
Purity:	98.02
Description:	NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only