Data Sheet

MSDS

AS2863619 (free base) [CAS 2241300-50-3]

CAS No:	2241300-50-3
Applications:	COVID-19-anti-virus
MW:	332.32
Formula:	C₁₆H₁₂N₈O
SMILES:	NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5
Purity:	99.87
Description:	AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only