Data Sheet

MSDS

ITI-214 (free base) [CAS 1160521-50-5]

CAS No:	1160521-50-5
Applications:	Neuroscience-Neuromodulation
MW:	507.56
Formula:	C₂₉H₂₆FN₇O
SMILES:	O=C(C1=C(NC2=CC=CC=C2)N(CC3=CC=C(C4=NC(F)=CC=C4)C=C3)N=C1N56)N(C)C5=N[C@@]7([H])[C@]6([H])CCC7
Purity:	98.0
Description:	ITI-214 free base is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 free base inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 free base shows efficacy in various animal models of motor and cognitive functions[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only