Data Sheet

MSDS

Raphin1 (acetate) [CAS 2242616-04-0] (10mM in DMSO)

CAS No:	2242616-04-0
Applications:	Neuroscience-Neurodegeneration
MW:	291.13
Formula:	C₁₀H₁₂Cl₂N₄O₂
SMILES:	N=C(N/N=C/C1=CC=CC(Cl)=C1Cl)N.CC(O)=O
Purity:	99.88
Description:	Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only