Data Sheet

MSDS

MRT199665 [CAS 1456858-57-3]

CAS No:	1456858-57-3
Applications:	Cancer-Kinase/protease
MW:	469.58
Formula:	C₂₈H₃₁N₅O₂
SMILES:	O=C1C(C)(C)C2=CN=C(NC3=CC=CC(CN4CCCC4)=C3)N=C2N1[C@H]5CCC6=C5C=CC=C6O
Purity:	99.92
Description:	MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPK?1/AMPK?2, and SIK1/SIK2/SIK3, respectively[1]. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells[2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[3].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only