Apcin [CAS 300815-04-7]
Partner: MedChemexpress LLC
| CAS No: | 300815-04-7 |
| Applications: | Cancer-programmed cell death |
| MW: | 438.65 |
| Formula: | C13H14Cl3N7O4 |
| SMILES: | O=C(OCCN1C([N+]([O-])=O)=CN=C1C)NC(NC2=NC=CC=N2)C(Cl)(Cl)Cl |
| Purity: | 99.12 |
| Description: | Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis[1][2][3]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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