Data Sheet

MSDS

NF157 [CAS 104869-26-3]

CAS No:	104869-26-3
Applications:	COVID-19-immunoregulation
MW:	1437.10
Formula:	C₄₉H₂₈F₂N₆Na₆O₂₃S₆
SMILES:	O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2F)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6F)=O)=CC=C5
Purity:	92.0
Description:	NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 �M, 170 �M for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 �M), P2Y2 (Ki=28.9 �M), respectively[1]. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA)[2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only