SKF-83566 [CAS 99295-33-7]
Partner: MedChemexpress LLC
| CAS No: | 99295-33-7 |
| Applications: | Neuroscience-Neuromodulation |
| MW: | 332.23 |
| Formula: | C17H18BrNO |
| SMILES: | OC1=C(Br)C=C2CCN(C)CC(C3=CC=CC=C3)C2=C1 |
| Purity: | 99.86 |
| Description: | SKF-83566 is a potent,�blood-brain permeable and orally active D1-like dopamine receptor (D1DR)�antagonist and a weaker competitive antagonist at the vascular 5-HT2�receptor (Ki=11 nM)[1][3]. SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50�of 5.7 ?M[2]. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta[4]. SKF-83566 can be used for research of parkinson�s disease and nicotine craving alleviation[5]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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