Ro 90-7501 [CAS 293762-45-5]
Partner: MedChemexpress LLC
| CAS No: | 293762-45-5 |
| Applications: | Neuroscience-Neurodegeneration |
| MW: | 340.38 |
| Formula: | C20H16N6 |
| SMILES: | NC1=CC=C2C(N=C(C3=CC=C4C(N=C(C5=CC=C(N)C=C5)N4)=C3)N2)=C1 |
| Purity: | 99.10 |
| Description: | Ro 90-7501 is an amyloid ?42 (A?42) fibril assembly inhibitor that reduces A?42-induced cytotoxicity (EC50 of 2 ?M). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-? gene expression and antiviral response[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells[4]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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