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Cat Number:AP6110A-ev

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Data Sheet


ABCB11 [C-term] [RB2211], Rabbit Polyclonal Antibody

Partner: Abcepta, Inc.

Applications:WB, IHC-P
Species Reactivity:Human, Mouse
Isotype:Rabbit Ig
Purification:Purified Rabbit Polyclonal Antibody
Description:ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Further Information:This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human ABCB11.
Synonym:Bile salt export pump, ATP-binding cassette sub-family B member 11, ABCB11, BSEP
Ascension Number:O95342
NCBI EntrezGene:8647
Shipping Conditions:Ship on cold packs
Storage:Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:Research use only


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The anti-ABCB11 C-term Pab (Cat. #AP6110a) is used in Western blot to detect ABCB11 in mouse liver tissue lysate.

The anti-ABCB11 C-term Pab (Cat. #AP6110a) is used in Western blot to detect ABCB11 in mouse liver tissue lysate.