Applications: | WB |
Species Reactivity: | Human, Mouse, Rat |
Isotype: | Rabbit Ig |
Purification: | Purified Rabbit Polyclonal Antibody |
Description: | Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. |
Further Information: | This ACO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 124-155 amino acids from human ACO1. |
Synonym: | Cytoplasmic aconitate hydratase, Aconitase, 4.2.1.3, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1 |
Ascension Number: | P21399 |
NCBI EntrezGene: | 48 |
Shipping Conditions: | Ship on cold packs |
Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
Usage: | Research use only |