| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | HLA-DRB4 belongs to the HLA class II beta chainparalogues. This class II molecule is a heterodimer consisting ofan alpha (DRA) and a beta (DRB) chain, both anchored in themembrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class IImolecules are expressed in antigen presenting cells (APC: Blymphocytes, dendritic cells, macrophages). The beta chain isapproximately 26-28 kDa and its gene contains 6 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the twoextracellular domains, exon 4 encodes the transmembrane domain andexon 5 encodes the cytoplasmic tail. Within the DR molecule thebeta chain contains all the polymorphisms specifying the peptidebinding specificities. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. DRB1 is expressedat a level five times higher than its paralogues DRB3, DRB4 andDRB5. The presence of DRB4 is linked with allelic variants of DRB1,otherwise it is omitted. There are 4 related pseudogenes: DRB2,DRB6, DRB7, DRB8 and DRB9. |
| Further Information: | This HLA-DRB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human HLA-DRB4. |
| Synonym: | HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4, HLA-DRB4 |
| Ascension Number: | P13762 |
| NCBI EntrezGene: | 3126 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
