Signet Genotyping Kits
Marligen’s Signet™ Genotyping Kits are designed to rapidly and accurately detect genetic variations including single nucleotide polymorphisms (SNPs), small insertions and deletions (indels) and whole gene deletions. SNPs and other genetic variants may be associated with a variety of health and nutritional conditions and have application in pharmacogenomics, nutrition, toxicology, and ancestry. The products offered include specific panels that are ready to use on the Luminex™ xMAP platform for multiplexed analysis.
Popular SignetTM Genotyping Testing Panels
Signet™ PG Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1800795 |
IL6 |
Promoter Variant |
G-174C |
rs328 |
LPL |
Ser447Stop |
C1421G |
rs1801131 |
MTHFR |
Glu429Ala |
A1298C |
rs4332 |
ACE |
Intronic Variant |
C547T |
rs1801133 |
MTHFR |
Ala222Val |
C677T |
rs5128 |
APOC3 |
3'UTR |
C3238G |
Signet™ PG Panel 2
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs234706 |
CBS |
Tyr233Tyr |
C33T |
GSTM1del |
GSTM1 |
Whole gene deletion |
--- |
GSTT1del |
GSTT1 |
Whole gene deletion |
--- |
rs1695 |
GSTP1 |
Ile105Val |
A342G |
rrs1801282 |
gPPAR |
Pro12Ala |
C167G |
rs1805087 |
MTR |
Asp919Gly |
A2756G |
rs1800796 |
IL6 |
Promoter Variant |
G-573C |
rs2228570 |
VDR |
creates a new upstream initiation codon |
C27823T |
rs708272 |
CETP |
Intronic Variant |
C>T |
Signet™ PG Panel 3
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1800629 |
TNFa |
Promoter Variant |
G-308A |
rs1801394 |
MTRR |
Ile22Met |
A66G |
rs731236 |
VDR |
3'UTR |
C352T |
Signet™ PG Panel 4
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1544410 |
VDR |
--- |
A>G |
rs1799983 |
eNOS |
Glu298Asp |
G894T |
rs1138272 (rs1799811) |
GSTP1 |
Ala114Val |
C341T |
SignetTM Obesity Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs266729 |
ADIPOQ |
--- |
–11377C>G |
rs1501299 |
ADIPOQ |
Intron |
G276T |
rs5030980 |
AGRP |
Ala67Thr |
Ala67Thr |
rs5443 |
GNB3 |
Ser275Ser |
C825T |
rs1143634 |
IL-1b |
Phe105Phe |
T3954C |
rs8192284 |
IL-6R |
Asp358Ala |
A1510C |
rs133068 |
MCHR1 |
Promoter Variant |
C>G |
rs16139 |
NPY |
Leu7Pro |
T106C |
rs3792267 |
CAPN10 |
Intron |
-43G>A |
rs1801282 |
PPARgG |
Pro12Ala |
C167G |
Signet™ Drug Metabolism Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs11642466 |
VKORC1 |
Intron |
A>G |
rs11642603 |
VKORC1 |
Chrom. 16 |
C>G |
rs2359612 |
VKORC1 |
Intron |
A>G |
rs4889490 |
VKORC1 |
3' near gene |
G>C |
rs4889537 |
VKORC1 |
3' near gene |
G>C |
rs4889599 |
VKORC1 |
5' near gene |
C>T |
rs7194347 |
VKORC1 |
Chr 16 |
A>T |
rs7294 |
VKORC1 |
3' UTR |
G>A |
rs9923231 |
VKORC1 |
5' near gene |
C>T |
rs9934438 |
VKORC1 |
Intron |
G>A |
Signet™ Drug Metabolism Panel 2
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1057910 |
CYP2C9 |
Ile359Leu |
A>C |
rs2860905 |
CYP2C9 |
Intron |
A>G |
rs3814637 |
CYP2C19 |
5' near gene |
C>T |
rs4917639 |
CYP2C9 |
Intron |
C>A |
rs9325473 |
CYP2C9 |
Intron |
A>G |
rs9332108 |
CYP2C9 |
Intron |
T>C |
rs17882687 |
CYP2C19 |
ILle19Leu |
A>C |
rs9332214 |
CYP2C9 |
Intron |
C>T |
Signet™ Drug Metabolism Panel 3
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1799809 |
PROC |
5’ near gene |
A>G |
rs2069901 |
PROC |
5’ near gene |
C>T |
rs2069910 |
PROC |
Intron |
C>T |
rs12714145 |
GGCX |
Intron |
C>T |
Signet™ Drug Metabolism Panel 4
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs5030838 |
CYP1A1*2A |
Genomic |
3801 T>C |
CYP1A1*6 |
CYP1A1*2A |
Met331Ile |
1636 G>T |
rs4987133 |
CYP1A1 |
Ile286Thr |
T>C |
rs2856833 |
CYP1A1 |
Phe381Leu |
C>A |
rs1799814 |
CYP1A1 |
Thr461Asn |
2453 C>A |
rs1048943 |
CYP1A1*2C |
Ile462Val |
2455 A>G |
rs2278970 |
CYP1A1 |
Ala463Gly |
C>G |
rs4986826 |
AhR |
Val570Ile |
1768 G>A |
rs1056836 |
CYP1B1*3 |
Leu432Val |
4326 C>G |
rs1800440 |
CYP1B1*4 |
Asn453Ser |
4390 A>G |
SignetTM Alzheimer’s Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs405509 |
APO E |
5' near gene |
C>A |
rs3745833 |
GALP |
Met72Ile |
G>C |
rs8192708 |
PCK1 |
Ile267Val |
A>G |
rs11622883 |
Near SERPINA13 |
--- |
T>A |
rs1554948 |
TNK1 |
Leu27Leu |
T>A |
rs157581 |
TOMM40 |
Phe113Phe |
G>A |
rs4420638 |
Chromosome 19 |
--- |
G>A |
Signet™ Hemochromatosis Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs334 |
HBB (HbS) |
Glu6Val |
GAG>GTG |
rs33930165 |
HBB (HbC) |
Glu6Lys |
GAG>AAG |
rs33950507 |
HBB (HbE) |
Glu26Lys |
GAG>AAG |
Signet™ Hemoglobinopathies Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs334 |
HBB (HbS) |
Glu6Val |
GAG>GTG |
rs33930165 |
HBB (HbC) |
Glu6Lys |
GAG>AAG |
rs33950507 |
HBB (HbE) |
Glu26Lys |
GAG>AAG |
Signet™ Cancer Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
CHEK2 1100delC |
CHEK2 |
-- |
delC |
GSTT1del |
GSTT1 |
Whole gene deletion |
-- |
rs1042522 |
TP53 |
Arg72Pro |
C>G |
rs1045485 |
CASP8 |
Asp302His |
G>C |
rs2987983 |
ESR2 |
-- |
-13,950 T>C |
rs619824 |
CYP17 |
-- |
-15,891 C>A |
rs7965399 |
IGF1 |
-- |
T>C |
Please click here to purchase a Marligen Genotyping Kit
In addition to the specific Signet™ Genotyping Panels, Marligen scientists can work with you to design, develop, and manufacture specific Custom Genotyping Assay Kits. Please contact us for more information
Click here for more information on Marligen’s genotyping technology.
Please click here for a description of other products and services offered by Marligen.
Signet™ Y-SNP Genotyping Kits
Marligen’s Signet™ Y-SNP Genotyping Kits have been designed to genotype male-specific markers on the Y-chromosome with applications in ancestry testing and population genetics. The Signet™ Y-SNP Genotyping Kits multiplex both the amplification and detection steps, allowing screening of >500 samples per day. Read more 
Advantages: |
- Simple assay protocol with no wash steps
- Rational design optimizes detailed genotyping of samples in just two runs
- Requires as little as 2ng of sample DNA per reaction
- Multiplexing increases productivity allowing the complete genotyping of >500 samples in 1 day
- Amelogenin marker included to verify gender of sample
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In addition to the Y-SNP Genotyping kits, Marligen’s scientists will work with you to design, develop, and manufacture specific custom multiplex Genotyping Assays to meet your research needs. Signet™ Genotyping Testing Services are also available.
All of Marligen Signet™ Genotyping Assays are configured to be used in conjunction with the Luminex™ System.
Click here for Signet™ Genotyping Kits
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