Signet™ Genotyping Testing
Marligen’s Signet™ Genotyping Panels are specific multiplexes that detect polymorphisms and gene variants associated with a variety of health and nutritional conditions including heart and bone health, antioxidant detoxification function, insulin sensitivity, inflammation, obesity and Alzheimer’s disease. These assays have application in nutrigenomics, pharmacogenomics, and toxicogenomics.
Please click here for a description of the Signet’s Genotyping testing technology and assay protocol. For information concerning procedures for shipping biological samples to Marligen, please click here.
Download the full list of panels. To request a quote or additional information for any of the following Signet™ Genotyping Panels, please contact Insight Biotech on Tel: +44(0)20 8385 0303), or email info@insightbio.com.
Popular SignetTM Genotyping Testing Panels
Signet™ PG Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1800795 |
IL6 |
Promoter Variant |
G-174C |
rs328 |
LPL |
Ser447Stop |
C1421G |
rs1801131 |
MTHFR |
Glu429Ala |
A1298C |
rs4332 |
ACE |
Intronic Variant |
C547T |
rs1801133 |
MTHFR |
Ala222Val |
C677T |
rs5128 |
APOC3 |
3'UTR |
C3238G |
SignetTM PG Panel 2
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs234706 |
CBS |
Tyr233Tyr |
C33T |
GSTM1del |
GSTM1 |
Whole gene deletion |
--- |
GSTT1del |
GSTT1 |
Whole gene deletion |
--- |
rs1695 |
GSTP1 |
Ile105Val |
A342G |
rrs1801282 |
gPPAR |
Pro12Ala |
C167G |
rs1805087 |
MTR |
Asp919Gly |
A2756G |
rs1800796 |
IL6 |
Promoter Variant |
G-573C |
rs2228570 |
VDR |
creates a new upstream initiation codon |
C27823T |
|
|
|
|
rs708272 |
CETP |
Intronic Variant |
C>T |
Signet™ PG Panel 3
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1800795 |
IL6 |
Promoter Variant |
G-174C |
rs328 |
LPL |
Ser447Stop |
C1421G |
rs1801131 |
MTHFR |
Glu429Ala |
A1298C |
rs4332 |
ACE |
Intronic Variant |
C547T |
rs1801133 |
MTHFR |
Ala222Val |
C677T |
rs5128 |
APOC3 |
3'UTR |
C3238G |
Signet™ PG Panel 4
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1544410 |
VDR |
--- |
A>G |
rs1799983 |
eNOS |
Glu298Asp |
G894T |
rs1138272 (rs1799811) |
GSTP1 |
Ala114Val |
C341T |
SignetTM Obesity Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs266729 |
ADIPOQ |
--- |
–11377C>G |
rs1501299 |
ADIPOQ |
Intron |
G276T |
rs5030980 |
AGRP |
Ala67Thr |
Ala67Thr |
rs5443 |
GNB3 |
Ser275Ser |
C825T |
rs1143634 |
IL-1b |
Phe105Phe |
T3954C |
rs8192284 |
IL-6R |
Asp358Ala |
A1510C |
rs133068 |
MCHR1 |
Promoter Variant |
C>G |
rs16139 |
NPY |
Leu7Pro |
T106C |
rs3792267 |
CAPN10 |
Intron |
-43G>A |
rs1801282 |
PPARgG |
Pro12Ala |
C167G |
Signet™ Drug Metabolism Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs11642466 |
VKORC1 |
Intron |
A>G |
rs11642603 |
VKORC1 |
Chrom. 16 |
C>G |
rs2359612 |
VKORC1 |
Intron |
A>G |
rs4889490 |
VKORC1 |
3' near gene |
G>C |
rs4889537 |
VKORC1 |
3' near gene |
G>C |
rs4889599 |
VKORC1 |
5' near gene |
C>T |
rs7194347 |
VKORC1 |
Chr 16 |
A>T |
rs7294 |
VKORC1 |
3' UTR |
G>A |
rs9923231 |
VKORC1 |
5' near gene |
C>T |
rs9934438 |
VKORC1 |
Intron |
G>A |
Signet™ Drug Metabolism Panel 2
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1057910 |
CYP2C9 |
Ile359Leu |
A>C |
rs2860905 |
CYP2C9 |
Intron |
A>G |
rs3814637 |
CYP2C19 |
5' near gene |
C>T |
rs4917639 |
CYP2C9 |
Intron |
C>A |
rs9325473 |
CYP2C9 |
Intron |
A>G |
rs9332108 |
CYP2C9 |
Intron |
T>C |
rs17882687 |
CYP2C19 |
ILle19Leu |
A>C |
rs9332214 |
CYP2C9 |
Intron |
C>T |
Signet™ Drug Metabolism Panel 3
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs1799809 |
PROC |
5’ near gene |
A>G |
rs2069901 |
PROC |
5’ near gene |
C>T |
rs2069910 |
PROC |
Intron |
C>T |
rs12714145 |
GGCX |
Intron |
C>T |
Signet™ Drug Metabolism Panel 4
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs5030838 |
CYP1A1*2A |
Genomic |
3801 T>C |
CYP1A1*6 |
CYP1A1*2A |
Met331Ile |
1636 G>T |
rs4987133 |
CYP1A1 |
Ile286Thr |
T>C |
rs2856833 |
CYP1A1 |
Phe381Leu |
C>A |
rs1799814 |
CYP1A1 |
Thr461Asn |
2453 C>A |
rs1048943 |
CYP1A1*2C |
Ile462Val |
2455 A>G |
rs2278970 |
CYP1A1 |
Ala463Gly |
C>G |
rs4986826 |
AhR |
Val570Ile |
1768 G>A |
rs1056836 |
CYP1B1*3 |
Leu432Val |
4326 C>G |
rs1800440 |
CYP1B1*4 |
Asn453Ser |
4390 A>G |
SignetTM Alzheimer’s Panel 1
Ref SNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
rs405509 |
APO E |
5' near gene |
C>A |
rs3745833 |
GALP |
Met72Ile |
G>C |
rs8192708 |
PCK1 |
Ile267Val |
A>G |
rs11622883 |
Near SERPINA13 |
--- |
T>A |
rs1554948 |
TNK1 |
Leu27Leu |
T>A |
rs157581 |
TOMM40 |
Phe113Phe |
G>A |
rs4420638 |
Chromosome 19 |
--- |
G>A |
*Sizes greater than 960 tests are available. Please contact us for more details.
Signet™ SNP Genotyping Kits are also available for you to perform your own assays on the Luminex® instrument.
Please click here for a description of other products and services offered by Marligen.
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